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In Brief: Colgate-Palmolive

This article was originally published in The Rose Sheet

Executive Summary

Colgate-Palmolive: Submits efficacy study results to FDA in support of monograph status for its 1.5% hydrogen peroxide-based Peroxyl Oral Rinse. Colgate found that viable bacteria in whole saliva were reduced 23%-35% and that Peroxyl showed activity against "most" of the test species. The two-part study included microbiological testing of whole saliva samples from subjects rinsing with the product and a determination of the minimum inhibitory concentration and minimum bactericidal concentrations against 37 strains of oral and non-oral microorganisms. The greatest activity was against gram negative anaerobic pathogens, Colgate reported. FDA's OTC oral antiseptics tentative final monograph currently does not include any Category I (safe and effective) ingredients ("The Rose Sheet" Feb. 14, 1994, p. 5)...
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