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In Brief: Galderma Differin -vs- J&J Retin-A

This article was originally published in The Rose Sheet

Executive Summary

Galderma Differin -vs- J&J Retin-A: Results from three Galderma studies comparing the irritation potential of Differen (adapalene .1%) in different gel vehicles with Retin-A (tretinoin gel .025%) found that adapalene gel "was very well tolerated when applied topically in standard cumulative irritation tests" and was relatively non-irritating when used on facial skin. Tretinoin under similar testing conditions "produced severe irritation reactions resulting in treatment discontinuation in many cases," according to the Galderma researchers. Galderma's analysis of two large multi-centered Phase I trials on the safety and efficacy of the two ingredients concluded that the 295 tretinoin users in both studies combined reported higher numbers of cutaneous events that the 296 adapalene users. Galderma has an NDA pending for adapalene 1%, a naphtholic acid derivative...
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