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Reduced animal toxicity test revisions released

This article was originally published in The Rose Sheet

Executive Summary

Interagency Center for the Evaluation of Alternative Toxicological Methods seeking public comment on its report on the revised Up-and-Down Procedure of acute oral toxicity testing in animals, National Institute for Environmental Health Sciences announces in Feb. 7 Federal Register notice. Comment deadline is March 25. Available on 1ICCVAM's Web site, the report includes scientific peer review of revised UDP and final test guidelines and will be transmitted to U.S. federal agencies following comment period. ICCVAM reviewed the procedure, an alternative to conventional means of evaluating LD50, in an October report (2"The Rose Sheet" Oct. 15, 2001, p. 9). UDP uses fewer animals than conventional methods...

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