Propylene glycol review
This article was originally published in The Rose Sheet
Executive Summary
Propylene glycol is of "negligible concern for reproductive or developmental toxicity in humans" at current estimated exposure levels, National Toxicology Program Center for the Evaluation of Risks to Human Reproduction Expert Panel concludes following Feb. 11-13 meeting in Alexandria, Va. Panel recommends collection of additional research to address some data gaps in humans and says one critical data need is long-term follow up of children and pregnant women exposed to high dose propylene glycol from continuous IV infusion via medical tubing. CERHR published a draft report on propylene glycol including some dermal absorption data in December (1"The Rose Sheet" Dec. 16, 2002, p. 9)...
You may also be interested in...
Propylene Glycol Dermal Absorption Data Included In CERHR Draft Report
Dermal absorption of propylene glycol across intact skin is likely to be slow, and any dermal exposure to the ingredient "will result in systematic levels far below saturation of metabolic clearance," according to a draft report by the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction
Japan Grants Global-First Approval To Zolbetuximab, 15 Other New Drugs
Astellas's first-in class CLDN18.2-targeting antibody receives its first approval worldwide, while crovalimab and a number of drugs for rare diseases also receive nods from regulators and are now awaiting reimbursement price-listing.
Hanmi-OCI Merger Hits Wall As Brothers Win Shareholder Vote, Board Seats
The planned merger of Korea's Hanmi Pharm Group with OCI Group hits a major speed bump as the two sons of Hanmi's founder and other candidates recommended by them secture board seats. But it remains to be seen how the Lim brothers will fulfil their ambitious promises.