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This article was originally published in The Rose Sheet

Executive Summary

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods announces availability of two updated standardized in vitro cytotoxicity test method protocols for estimating acute oral systemic toxicity in rodents in Oct. 19 Federal Register notice. Protocols were recommended by Interagency Coordinating Committee on the Validation of Alternative Methods for determining starting doses for in vivo acute oral systemic tests to reduce the number of animals necessary in testing. NICEATM also requests data on chemicals and products tested for acute oral systemic toxicity and in vitro cytotoxicity using the standardized test method protocols. Data will be used to determine usefulness of cytotoxicity methods for estimating in vivo acute oral toxicity and investigate other methods to improve accuracy of in vitro assessments of acute systemic toxicity. Agency currently is accepting comments...

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