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NICEATM

This article was originally published in The Rose Sheet

Executive Summary

National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods announces availability of two updated standardized in vitro cytotoxicity test method protocols for estimating acute oral systemic toxicity in rodents in Oct. 19 Federal Register notice. Protocols were recommended by Interagency Coordinating Committee on the Validation of Alternative Methods for determining starting doses for in vivo acute oral systemic tests to reduce the number of animals necessary in testing. NICEATM also requests data on chemicals and products tested for acute oral systemic toxicity and in vitro cytotoxicity using the standardized test method protocols. Data will be used to determine usefulness of cytotoxicity methods for estimating in vivo acute oral toxicity and investigate other methods to improve accuracy of in vitro assessments of acute systemic toxicity. Agency currently is accepting comments...

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NICEATM request

National Toxicology Program Interagency Center on Evaluation of Alternative Toxicological Methods requests nominations for scientists to sit on expert panel that will evaluate the validation status of two in vitro cytotoxicity assays for estimating in vivo acute oral toxicity in March 22 Federal Register 1notice. ICCVAM would consider the panel's conclusions in developing test method recommendations and performance standards, agency adds. Nominations should be sent to NICEATM Director William Stokes by May 6. NICEATM also is requesting data on standard in vivo acute oral toxicity and in vitro cytotoxicity tests. Agency announced the availability of the test protocols in October (2The Rose Sheet" Oct. 25, 2004, In Brief)...

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