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Vitamins E And C Trial Shows No CVD-Prevention Benefits In “Healthy” Men

This article was originally published in The Tan Sheet

Executive Summary

A study finding no link between vitamin E or vitamin C supplementation and cardiovascular disease prevention in men was conducted using subjects largely regarded as healthy - a population that supplement industry stakeholders have called the true measuring stick for evaluating nutrient benefits

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Research & Development In Brief

Trade groups contest negative ginkgo study: A recently published study that found ginkgo biloba does not slow cognitive decline in older adults "should not be viewed as the final word" on the supplement's benefit, the Council for Responsible Nutrition argues. "There is a large body of previously published evidence" and ongoing clinical trials that suggest "ginkgo may improve cognitive impairment in older adults," says CRN VP of Scientific and Regulatory Affairs Douglas MacKay in a Dec. 29 statement. The study, published in the Journal of the American Medical Association, found the annual rates of decline of memory, attention, visual-spatial abilities, language and executive function of the 1,545 participants who took a 120-mg dose of ginkgo twice daily were the same as for 1,524 participants who took a placebo for an average of 6.1 years. The study, led by Beth Snitz at the Neurology Department at the University of Pittsburgh, is a secondary analysis of the Ginkgo Evaluation of Memory study, originally published in November 2008. The American Herbal Products Association complains the data review had "the same limitations as the original GEM study" and was not "ideally suited for this new endpoint.

JAMA Vitamin E Citation Report Supports Looking Past Traditional Trial Model

A Journal of the American Medical Association report on citations of observational studies that show a cardiovascular benefit for vitamin E adds support for looking beyond the clinical trial model for supplement evidence, according to the Council for Responsible Nutrition

Industry, Researchers Pan Study Showing Antioxidants May Up Mortality Risk

Trade groups and researchers say faulty methodology was used in a meta-analysis concluding that antioxidant supplements may increase mortality risk

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