FDA Science Forum In Brief
This article was originally published in The Rose Sheet
Executive Summary
Retinol absorption: Anti-aging ingredient retinol was found to form a rat skin reservoir both in vivo and in vitro in percutaneous absorption study, according to J.J. Yourick et al., Center for Food Safety & Applied Nutrition Office of Cosmetics and Colors. Method, which was outlined in poster abstract presented during 2006 FDA Science Forum in Washington, D.C. April 18-20, assesses percutaneous absorption of retinol from cosmetic formulas to predict systemic absorption and significance of the skin reservoir. Test protocol involved exposing viable skin from rats and humans to .3% retinol formulas for 24 hours or 72 hours. Results of in vitro rat skin studies revealed 23% retinol was found in skin and 6% in receptor fluid at 24 hours, while in vivo rat studies showed 4% systemic absorption of retinol after 24 hours. The Cosmetic Ingredient Review Expert Panel considered retinols for re-review last year, but decided not to re-open the ingredient based on safety data submitted by industry (1"The Rose Sheet" June 20, 2005, p. 3)...
You may also be interested in...
CIR Reopens N-Butyl Alcohol Review To Address Non-Nail Uses
The Cosmetic Ingredient Review Expert Panel is reopening its safety assessment of n-butyl alcohol to create a tentative addendum incorporating the use of the substance in non-nail care formulas, the panel announced during a June 13-14 meeting in Washington, D.C
OCA Applauds Organic Board's Recommendation To USDA: "Outlaw Nanotech"
With a push from the Organic Consumers Association, the National Organic Standards Board is recommending that the use of nanotechnology be strictly prohibited from products certified under the National Organic Program
Beauty Claims Inch Closer To Pharma As Cosmeceutical Sector Expands
Though global market-size estimates differ, analysts at SupplySide West 2010 in Las Vegas agreed that cosmeceuticals remain a promising growth vehicle