Murine LLNA Alternative Animal Test Approved, Sent To Federal Agencies
This article was originally published in The Rose Sheet
Executive Summary
The Inter-Agency Coordinating Committee for the Validation of Alternative Methods has approved the murine local lymph node assay (LLNA) as a viable alternative in assessing allergic contact dermatitis to the guinea pig maximization test or the Buehler assay. ICCVAM is a National Institutes of Health committee charged with finding alternatives to animal testing.
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Animal testing
Murine local lymph node assay accepted by FDA, the Environmental Protection Agency, Consumer Product Safety Commission and Occupational Safety & Health Administration as an alternative test method for contact dermatitis, the National Institutes of Health announces Dec. 28. The mouse trials can be conducted using fewer animals in most situations, NIH says. The LLNA test also results in less stress on the mice and can be conducted within a week, compared to three to four weeks for the guinea pig test. LLNA was accepted as a viable alternative to guinea pig tests by the Inter-Agency Coordinating Committee for the Validation of Alternative Methods in early 1999 and sent to the federal agencies for review (1"The Rose Sheet" March 29, 1999, p. 9). The assay is the first to clear the validation process
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