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Ocular Irritation Assay Data Deemed Incomplete By ICCVAM Panel

This article was originally published in The Rose Sheet

Executive Summary

Existing data are inadequate to determine whether the Isolated Rabbit Eye test method can identify severe ocular irritants or corrosives under a tiered testing strategy, the Interagency Coordinating Committee on the Validation of Alternative Methods expert panel concluded during a Jan. 11-12 meeting in Bethesda, Md

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NICEATM Wants Data To Evaluate In Vitro Tests For Nonsevere Ocular Irritants

The National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) is soliciting ocular irritation test data from human, rabbit and in vitro studies to expand its ocular toxicity database and assess the efficacy of four in vitro test methods in identifying nonsevere ocular irritants

NICEATM Wants Data To Evaluate In Vitro Tests For Nonsevere Ocular Irritants

The National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) is soliciting ocular irritation test data from human, rabbit and in vitro studies to expand its ocular toxicity database and assess the efficacy of four in vitro test methods in identifying nonsevere ocular irritants

ICCVAM

Interagency Coordinating Committee for the Validation of Alternative Methods likely will issue a draft report on four in vitro tests for detecting ocular corrosives and severe irritants to benefit downstream users, despite the fact the document will contain similar conclusions to separate background review documents released in 2004, NICEATM Deputy Director Raymond Tice, PhD, says during a Sept. 19 teleconference. ICCVAM expert panel meeting addressed reanalyzed data on the four tests - Isolated Rabbit Eye, Isolated Chicken Eye, Bovine Corneal Opacity and Permeability and Hen's Egg Test - Chorioallantoic Membrane, which were released in July (1"The Rose Sheet" Aug. 1, 2005, p. 9). However, panel's conclusions were largely unchanged from those expressed during its January meeting (2"The Rose Sheet" Jan. 17, 2005, p. 4). Agency should undertake "some kind of critical review to see whether or not it's worthwhile moving forward" with reviews of HET-CAM and ICE, according to panel member Roger Beuerman, PhD...

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